◎ 제 275차 한림의학세미나 개최 ◎


▶ 일 시 : 2017. 4. 4(화) 16시

▶ 장 소 : 대학원의학과 세미나실(의학관 5층 3506호실)

▶ 연 자 : 박재용 교수(고려대학교 보건과학대학)

▶ 주 최 : 의과대학 의과학연구소 / 미생물학교실

▶ 강의제목 : Physiological functions of TWIK-1 in the brain

　Although TWIK-1 is the first identified member of two-pore domain K+(K2P) channelsthatplayanessentialpartintheregulationofrestingmembranepotentialandcellularexcitability,thephysiologicalrolesofTWIK-1inthebrainarerecentlybeingstudiedindepth.AseriesofourrecentstudiessuggestthatTWIK-1underlievariousfunctionsuchas intrinsic excitability of neurons, astrocytic passive conductance, and astrocytic glutamate release as homodimer or heterodimer with other K2P isotypes. Here, I review newly identified functions of TWIK-1 in the brain based on the recent our studies demonstrating the pivotal functions of TWIK-1.



▶ Education and Professional Career:
1987-1994 Graduated from Department of Genetic engineering, Korea University
1990-1992 Discharged from Military Service
1995-1997 M. S. degree from Department of Molecular Biology, Graduate School, Seoul National University
1997-2001 Ph. D degree from Department of Life Sciences, Graduate School, Seoul National University
2001-2002 Senior Scientist, Neurogenex, Inc.
2002-2004 Lecturer, Department of Physiology, GNU School of Medicine
2004-2008 Assistant Professor, Department of Physiology, GNU School of Medicine
2008-2013 Associate Professor, Department of Physiology, GNU School of Medicine
2013-2014 Professor, Department of Physiology, GNU School of Medicine
2014.9- Professor, School of Biosystem and Biomedical Science, College of Health Science, Korea University


▶ Selected recent papers:
Suppression of 14-3-3g-mediated surface expression of ANO1 inhibits cancer progression of glioblastoma cells. Scientific Reports. 2016 May; 6:26413.
Physiological functions of the TRPM4 channels via protein interactions. BMPRep.2015Jan;48(1):1-5.
TWIK-1 contributes to the intrinsic excitability of dentate granule cells in mouse hippocampus. MolBrain.2014Nov19;7(1):80.
Light-inducible receptor tyrosine kinases that regulate neurotrophin signaling. NatureCommunications.2014Jun4;doi:10.1038/ncomms5057.
Heterodimer of TWIK-1 and TREK-1 mediates passive conductance and glutamate release in astrocytes. Nature Communications. 2014 Feb 05; doi: 10.1038/ncomms4227.
Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation. ProcNatlAcadSciUSA. 2013 Apr 2;110(14):5677-82.
TREK-1 and Best1 Channels Mediate Fast and Slow Glutamate Release in Astrocytes upon GPCR Activation. Cell.2012Sep28;151(1):25-40.



▶ Research interests:
· Ion channel interactomics (mechanism of trafficking, regulation and degradation of astrocytic ion channels based on protein-protein interaction)
· Physiology of astrocyte-neuron interaction (mechanism of glutamate release, passive conductance and volume regulation in astrocytes)
· Ion channels and cancers